Natrix HD-Sb

Natrix HD-Sb Hydrogel Membrane

Salt-tolerant cation exchange membrane augmented with HIC groups
for Purification of Monoclonal Antibodies

Discover the new Natrix Recon HD-Sb Membrane Device for lab scale process exploration and DOE work. Low pressure Recon devices are compatible with all benchtop chromatography systems, ready-to-use with Luer Lock fittings. Larger devices for process development and clinical manufacturing are currently under development.

  • Extremely fast Capture or Polishing
     
  • Very high dynamic binding capacity, excellent monomer recovery and high aggregate clearance
     
  • High salt tolerance for robust processes

Explore the future of disposable downstream processing!
The next in the Natrix line of products for clinical manufacturing, the new Recon HD-Sb membrane device will soon be available for lab scale process exploration and DOE work. Low pressure Recon devices are compatible with all benchtop chromatography systems, ready-to-use with Luer Lock fittings. Larger devices for process development and clinical manufacturing are currently under development.


High Binding Capacity and high speed polishing with proven Natrix HD hydrogel technology
The high ligand density and excellent mass transfer of the three-dimensional macroporous hydrogel give a binding capacity >90 mg mAb/ml of membrane (10% breakthrough) at flow rates of 10 MV/min or greater (residence time of 6 seconds or less). In flowthrough mode, a single 0.8 ml Recon device can polish 250 mg of monoclonal antibody in one step.
 

High Aggregate Clearance and HCP Removal by mixed-mode chemistries
The HD-Sb membrane is a mixture of strong cation exchange (sulfonic acid) and hydrophobic (t-butyl) groups. This unique chemistry achieves highly purified antibodies in both bind & elute and flowthrough modes.

 

Learn More - Download the Natrix HD-Sb Overview